Scientist I, Biomarker Assay Development, Translational Science

Company: Horizon Therapeutics
Location: Arlington
Posted on: May 23, 2023

Job Description:

At Horizon Therapeutics, we define success by the number of lives touched, lives changed, and lives saved. Our global biotechnology company is made up of agile, out-of-the-box thinkers with a focus on delivering breakthrough medicines to those living with rare, autoimmune, and severe inflammatory diseases. This is the heart of our global mission. Start a career that enables you to live up to your potential and help others live up to theirs. Join us.
The exceptional support we provide patients and communities equally extends to our employees. We offer industry-leading and award-winning benefits, compensation and rewards programs that positively impact all areas of our employees' personal and professional lives.
Position Summary
The Translational Medicine (TM) team is seeking a highly motivated Scientist I to lead the development of target engagement, pharmacodynamic and biomarker assays, in the context of drug development across the Horizon pipeline and a variety of therapeutic areas. The candidate will be responsible for the design, development, optimization, validation and execution of assays, as well as interacting with and managing vendors and contract research organizations (CROs).
Responsibilities

• Drive, design and lead assay development, validation and optimization of a variety of biochemical and cell based assays
• Maintain awareness of novel approaches and technologies to identify opportunities to improve current procedures and/or establish new assay platforms
• Identify and proactively troubleshoot technical issues, implement solutions under limited supervision
• Manage CROs to establish assay development, assay validation and assay transfer for biomarkers to appropriate regulatory standards
• Strong understanding of the drug development process
• Build strong and collaborative relationships across functions to establish and manage timelines, workflows, and documentation. Responding appropriately and quickly to changing priorities to meet timelines
• Review data generated by CROs on clinical samples using validated assays; quality control the data and summarize inconsistencies and outliers
• Engage and communicate effectively with CROs and TM team members to deliver quality-controlled data to support internal decision making
  Qualifications and Skills Required
  
  • A BSc in Biological science, biotechnology or related field with 4+ years of relevant assay development and industry experience
  • Track record of successful design, optimization and execution of assays for drug development
  • Ability to work in a fast-paced environment with rapidly changing and competing priorities and ambiguity.
  • Demonstrated success using in-house and external resources to develop, optimize and validate assays
  • Prior experience with pre-clinical or clinical drug development teams is preferred
  • Familiarity with a variety of assay platforms and a strong bioanalytical mindset
  • Experience in multi-color flow cytometry preferred, including analysis using softwares such as FlowJo and FCS Express
  • Lab work will be required; perform lab work independently
  • Strong planning, organization, and project management skills
  • Professional, proactive demeanor; Strong interpersonal skills; Excellent written and verbal communication skills.
    Our Values
    
    • Transparency: We value collaboration. Trusting teach other and tackling tough challenges can make a powerful difference.
    • Accountability: We do what's right for our patient communities through quality decisions and owning our successes and failures.
    • Growth: We fiercely innovate and evolve to better ourselves, our communities and our patients.
      These three values come to life through our five Leadership Expectations that apply to all Horizon employees
      
      • Enterprise Mindset: Look beyond one's team, brand or function to see the broader company and external perspective
      • Exhibit Intellectual Curiosity: Seek to understand what you do not know; ask the right questions of the right people and sources
      • Ensure Accountability and Courage: Step up to address difficult issues and hold self and others accountable to commitments
      • Embrace Diverse Perspectives: Welcome others with a respectful attitude; integrate diverse perspectives into ways of working
      • Develop Talent: Provide feedback, coaching and mentorship to help others be more effective in their role
        At Horizon, we know that disease does not discriminate. We embrace the bold ideas of one another, foster a sense of belonging, and value inclusion. We attract and develop diverse talent because we believe that when people from different backgrounds and life experiences come together, we make lives better.
        Horizon intends that all qualified applications are given equal opportunity, and that selection decisions be based on job-related factors. We do not discriminate based on race, color, religion, gender, sexual orientation, national origin, age, disability, veteran status, or any other characteristics protected by law.

Keywords: Horizon Therapeutics, Arlington , Scientist I, Biomarker Assay Development, Translational Science, Other , Arlington, Virginia